% 1. Title: Hepatocellular Carcinoma Dataset (HCC dataset) % % 2. Source Information % -- Donors of database: % Miriam Seoane Santos (miriams@student.dei.uc.pt) % Pedro Henriques Abreu (pha@dei.uc.pt) % Department of Informatics Engineering, University of Coimbra, Portugal % % Armando Carvalho(aspcarvalho@gmail.com) % Adélia Simão (adeliasimao@gmail.com) % Hospital and University Centre of Coimbra % % -- Date: Feb, 2015 % % % 3. Past Usage: % Miriam Seoane Santos, Pedro Henriques Abreu, Pedro J. Garcia-Laencina, % Adelia Simão, Armando Carvalho, “A new cluster-based oversampling method for % improving survival prediction of hepatocellular carcinoma patients”, % Journal of biomedical informatics, 58, 49-59, 2015. % % -- Proposed a cluster-based oversampling approach robust to small and imbalanced % datasets, accounting for the heterogeneity between HCC patients. The new approach % is based on K-means clustering and a modification of SMOTE algorithm. % % -- The approach was coupled with NN and LR and compared to baseline approaches that do % not consider clustering and/oversampling. % % -- The target was the first-year survival of the patients, and the results were % evaluated in terms of Accuracy, AUC values and F-measure. % % -- Data imputation was performed with KNN with the HEOM metric. % % -- The proposed approach (particularly, Augmented Sets Approach) coupled with NN % presented better results regarding Accuracy (0.7519), AUC (0.7) and F-measure (0.6650). % % % 4. Relevant Information: % HCC dataset was obtained at a University Hospital in Portugal and contais several % demographic, risk factors, laboratory and overall survival features of 165 real % patients diagnosed with HCC. The dataset contains 49 features selected according to % the EASL-EORTC (European Association for the Study of the Liver - European Organisation % for Research and Treatment of Cancer) Clinical Practice Guidelines, % which are the current state-of-the-art on the management of HCC. % % This is an heterogeneous dataset, with 23 quantitative variables, and 26 % qualitative variables. Overall, missing data represents 10.22% of the whole dataset % and only eight patients have complete information in all fields (4.85%). % The target variables is the survival at 1 year, and was encoded as a binary % variable: 0 (die) and 1 (lives). A certain degree of class-imbalance is also present % (63 cases labeled as “dies” and 102 as “lives”). A detailed description of the HCC % dataset (feature’s type/scale, range, mean/mode and missing data percentages) % is provided in Santos et al. “A new cluster-based oversampling method for % improving survival prediction of hepatocellular carcinoma patients”, % Journal of biomedical informatics, 58, 49-59, 2015. % % % % 5. Number of Instances: 165 % % 6. Number of Attributes: 49 + the class attribute % % % 7. Attribute Information: % % Name Data Type Abbreviation Range/Possible Values Missing Values(%) % ------ ---------- ------------ ---------------------- ------------------ % Gender nominal Gender (1=Male;0=Female) 0 % Symptoms nominal Symptoms (1=Yes;0=No) 10.91 % Alcohol nominal Alcohol (1=Yes;0=No) 0 % Hepatitis B Surface Antigen nominal HBsAg (1=Yes;0=No) 10.3 % Hepatitis B e Antigen nominal HBeAg (1=Yes;0=No) 23.64 % Hepatitis B Core Antibody nominal HBcAb (1=Yes;0=No) 14.55 % Hepatitis C Virus Antibody nominal HCVAb (1=Yes;0=No) 5.45 % Cirrhosis nominal Cirrhosis (1=Yes;0=No) 0 % Endemic Countries nominal Endemic (1=Yes;0=No) 23.64 % Smoking nominal Smoking (1=Yes;0=No) 24.85 % Diabetes nominal Diabetes (1=Yes;0=No) 1.82 % Obesity nominal Obesity (1=Yes;0=No) 6.06 % Hemochromatosis nominal Hemochro (1=Yes;0=No) 13.94 % Arterial Hypertension nominal AHT (1=Yes;0=No) 1.82 % Chronic Renal Insufficiency nominal CRI (1=Yes;0=No) 1.21 % Human Immunodeficiency Virus nominal HIV (1=Yes;0=No) 8.48 % Nonalcoholic Steatohepatitis nominal NASH (1=Yes;0=No) 13.33 % Esophageal Varices nominal Varices (1=Yes;0=No) 31.52 % Splenomegaly nominal Spleno (1=Yes;0=No) 9.09 % Portal Hypertension nominal PHT (1=Yes;0=No) 6.67 % Portal Vein Thrombosis nominal PVT (1=Yes;0=No) 1.82 % Liver Metastasis nominal Metastasis (1=Yes;0=No) 2.42 % Radiological Hallmark nominal Hallmark (1=Yes;0=No) 1.21 % Age at diagnosis integer Age 20-93 0 % Grams of Alcohol per day continuous Grams/day 0-500 29.09 % Packs of cigarets per year continuous Packs/year 0-510 32.12 % Performance Status* ordinal PS [0,1,2,3,4,5] 0 % Encephalopathy degree* ordinal Encephalopathy [1,2,3] 0.61 % Ascites degree* ordinal Ascites [1,2,3] 1.21 % International Normalised Ratio* continuous INR 0.84-4.82 2.42 % Alpha-Fetoprotein (ng/mL) continuous AFP 1.2-1810346 4.85 % Haemoglobin (g/dL) continuous Hemoglobin 5-18.7 1.82 % Mean Corpuscular Volume (fl) continuous MCV 69.5-119.6 1.82 % Leukocytes(G/L) continuous Leucocytes 2.2-13000 1.82 % Platelets (G/L) continuous Platelets 1.71-459000 1.82 % Albumin (mg/dL) continuous Albumin 1.9-4.9 3.64 % Total Bilirubin(mg/dL) continuous Total Bil 0.3-40.5 3.03 % Alanine transaminase (U/L) continuous ALT 11-420 2.42 % Aspartate transaminase (U/L) continuous AST 17-553 1.82 % Gamma glutamyl transferase (U/L) continuous GGT 23-1575 1.82 % Alkaline phosphatase (U/L) continuous ALP 1.28-980 1.82 % Total Proteins (g/dL) continuous TP 3.9-102 6.67 % Creatinine (mg/dL) continuous Creatinine 0.2-7.6 4.24 % Number of Nodules integer Nodules 0-5 1.21 % Major dimension of nodule (cm) continuous Major Dim 1.5-22 12.12 % Direct Bilirubin (mg/dL) continuous Dir. Bil 0.1-29.3 26.67 % Iron (mcg/dL) continuous Iron 0-244 47.88 % Oxygen Saturation (%) continuous Sat 0-126 48.48 % Ferritin (ng/mL) continuous Ferritin 0-2230 48.48 % Class Attribute nominal Class (1=lives;0=dies) 0 % % % (*) Adicional Info: % PS: [0=Active;1=Restricted;2=Ambulatory;3=Selfcare;4=Disabled;5=Dead]. In this dataset there are only PS from 0 to 4. % Encephalopathy degree: [1=None;2=Grade I/II; 3=Grade III/IV] % Ascites degree: [1=None;2=Mild;3=Moderate to Severe] % % % More information on HCC dataset’s features can be found in Santos et al. “A new cluster-based oversampling method % for improving survival prediction of hepatocellular carcinoma patients”, Journal of biomedical informatics, 58, 49-59, 2015. % % % 8. Missing Attribute Values: Denoted by “?”. Missing percentages for each attribute are specified above. % % 9. Class Distribution: % 2 classes: % 63 patients labeled as “dies” (0) % 102 patients labeled as “lives” (1) % @relation hcc-data @attribute Gender {1,0} @attribute Symptoms {1,0} @attribute Alcohol {1,0} @attribute HBsAg {1,0} @attribute HBeAg {1,0} @attribute HBcAb {1,0} @attribute HCVAb {1,0} @attribute Cirrhosis {1,0} @attribute Endemic {1,0} @attribute Smoking {1,0} @attribute Diabetes {1,0} @attribute Obesity {1,0} @attribute Hemochro {1,0} @attribute AHT {1,0} @attribute CRI {1,0} @attribute HIV {1,0} @attribute NASH {1,0} @attribute Varices {1,0} @attribute Spleno {1,0} @attribute PHT {1,0} @attribute PVT {1,0} @attribute Metastasis {1,0} @attribute Hallmark {1,0} @attribute Age numeric @attribute Grams_day numeric @attribute Packs_year numeric @attribute PS {0,1,2,3,4,5} @attribute Encephalopathy {1,2,3} @attribute Ascites {1,2,3} @attribute INR numeric @attribute AFP numeric @attribute Hemoglobin numeric @attribute MCV numeric @attribute Leucocytes numeric @attribute Platelets numeric @attribute Albumin numeric @attribute Total_Bil numeric @attribute ALT numeric @attribute AST numeric @attribute GGT numeric @attribute ALP numeric @attribute TP numeric @attribute Creatinine numeric @attribute Nodules numeric @attribute Major_Dim numeric @attribute Dir_Bil numeric @attribute Iron numeric @attribute Sat numeric @attribute Ferritin numeric @attribute Class {1,0} @data 1,0,1,0,0,0,0,1,0,1,1,?,1,0,0,0,0,1,0,0,0,0,1,67,137,15,0,1,1,1.53,95,13.7,106.6,4.9,99,3.4,2.1,34,41,183,150,7.1,0.7,1,3.5,0.5,?,?,?,1 0,?,0,0,0,0,1,1,?,?,1,0,0,1,0,0,0,1,0,0,0,0,1,62,0,?,0,1,1,?,?,?,?,?,?,?,?,?,?,?,?,?,?,1,1.8,?,?,?,?,1 1,0,1,1,0,1,0,1,0,1,0,0,0,1,1,0,0,0,0,1,0,1,1,78,50,50,2,1,2,0.96,5.8,8.9,79.8,8.4,472,3.3,0.4,58,68,202,109,7,2.1,5,13,0.1,28,6,16,1 1,1,1,0,0,0,0,1,0,1,1,0,0,1,0,0,0,0,0,0,0,1,1,77,40,30,0,1,1,0.95,2440,13.4,97.1,9,279,3.7,0.4,16,64,94,174,8.1,1.11,2,15.7,0.2,?,?,?,0 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0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,?,?,?,45,0,0,0,1,1,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,?,1 1,1,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,1,1,1,1,1,0,66,?,?,1,1,2,1.64,16,14,102.9,11.5,277000,3.1,6.8,140,244,795,595,7.2,0.79,1,2.3,4.1,63,34,888,0 1,1,0,0,0,0,0,0,0,1,1,0,0,1,1,0,1,0,0,0,0,0,0,80,0,80,0,1,1,1.33,163,10.6,96.2,9900,280000,3.3,1,28,57,236,171,7.5,1.38,1,19,?,45,21,802,0 1,?,1,0,?,1,0,1,0,1,0,0,0,0,0,0,0,1,1,1,0,0,0,58,?,40,0,1,1,1.49,20,15,96.7,9,78,4.6,2.1,40,49,137,109,7.6,0.8,1,2,0.4,184,59,905,1 0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,?,0,0,0,1,1,27,0,0,2,1,1,0.97,46,10.5,78.7,20.9,251,2.4,0.3,31,185,91,539,5,0.38,5,20,0.3,?,?,?,0 0,0,1,?,?,?,1,1,?,0,1,0,0,0,0,0,0,?,1,1,0,1,0,73,100,0,0,1,1,1.2,41470,12.6,91.4,12,275000,3.11,2.3,55,94,394,350,7.3,1.7,5,?,0.8,84,37,497,0 1,1,1,0,0,0,0,1,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,73,?,0,0,1,1,1.33,4.7,11.8,80.2,3.7,99,4.1,0.7,50,47,67,62,7.4,0.77,1,2.3,?,104,37,635,1 1,?,1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1,1,1,0,0,1,50,?,0,0,1,1,1.65,7.3,15.3,93.7,3500,57000,?,1.4,111,93,294,130,?,0.76,2,2,0.3,184,2.26,59,1 1,1,1,0,0,0,1,1,?,1,0,?,?,0,0,0,?,1,1,1,1,0,1,51,100,30,3,1,2,1.35,1898,12.4,95.1,9.8,216,2.7,8.2,164,523,433,397,6.7,0.82,1,2.1,5.5,56,27,742,0 0,1,0,?,?,?,1,0,0,0,1,0,?,1,0,?,?,0,?,0,0,1,1,78,0,0,1,1,1,1.32,77,10.8,88,6000,174000,3.2,0.9,48,19,171,923,5.4,1.31,3,15.4,?,?,?,?,0 1,1,1,0,?,?,?,1,0,1,1,0,?,1,0,0,?,0,0,1,0,0,1,81,100,10,2,1,2,3.56,2.7,7.3,90.8,2.42,159000,3.4,0.5,25,32,80,55,6.2,0.85,1,2.2,?,22,6,48,0 1,?,1,0,0,0,0,1,0,1,1,0,0,1,0,0,0,1,0,1,0,0,1,65,100,?,0,1,1,1.24,2.6,10.3,83,6.1,1.71,3.9,0.8,11,28,77,120,7,0.58,1,4.7,0.85,32,10,18,1 1,?,1,0,0,0,0,1,0,0,1,?,?,0,0,0,?,1,1,1,0,0,1,72,70,0,3,2,2,1.96,12,10.9,102,4.1,99,1.9,4.2,73,85,470,263,7,0.99,1,8.5,1.9,44,20,176,0 1,1,0,?,?,?,?,0,0,1,1,0,?,1,1,?,0,0,0,0,0,0,0,82,0,?,0,1,1,1.11,?,18.7,92.4,6900,270000,4,0.9,35,73,115,103,6.8,1.24,1,10,?,?,?,?,0 1,1,0,1,0,1,0,1,1,1,0,0,0,0,0,0,0,1,1,1,1,0,1,76,0,50,1,1,3,1.28,608,12.6,100,5.4,129,4,1.7,107,99,125,100,7.5,0.9,5,3.5,0.5,?,?,?,1 1,1,1,0,0,1,1,1,0,1,0,0,0,0,0,0,0,1,1,1,0,0,1,56,100,40,0,2,2,1.46,41,14.6,100.8,5.5,42000,3.1,3.7,121,165,101,207,6.3,0.69,1,3,1.9,224,95,363,1 0,0,1,0,0,0,0,1,0,1,0,1,0,0,0,0,0,1,1,1,0,0,1,68,?,30,2,1,2,1.94,?,11.5,97.4,5700,77000,2.7,4.9,34,48,46,178,6.1,0.62,1,4.6,2.2,?,?,?,1 1,1,1,0,0,0,0,1,0,1,1,0,0,1,0,0,0,1,1,1,0,0,1,72,300,?,3,1,3,1.57,2,12.6,96.6,2.9,76000,3.5,2.4,33,40,110,166,?,0.77,1,2,0.5,?,?,?,1 1,0,0,0,0,0,0,0,0,0,1,0,0,1,0,0,?,?,?,?,0,0,0,66,0,0,0,1,1,1.29,7,12.1,95.1,3.8,77000,3.8,1.4,37,38,194,161,6.7,0.71,1,10,0.5,0,0,0,1 0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,?,?,0,0,1,0,40,0,0,2,1,1,1.17,3.1,15.1,86,8.9,275000,2.8,1.3,74,50,23,104,5.4,0.6,5,7.8,0.2,46,18,?,0 1,?,1,0,?,1,0,1,0,1,0,0,0,0,0,0,0,?,1,1,0,0,1,68,60,?,0,1,1,1.34,13,15.6,93,4.9,91000,4.54,1.4,54,52,275,113,7.8,0.55,2,6.2,0.3,94,33,393,1 1,1,1,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,63,100,0,0,1,1,2.07,1.7,9.5,99.2,3300,79000,2.1,1.6,56,82,134,113,37,0.4,1,2.7,0.2,94,37,48,1 1,1,1,0,0,0,0,1,0,0,1,0,0,0,0,0,0,?,1,1,0,1,1,72,100,0,0,1,2,1.3,249,12.7,100.3,5.5,114,3.1,3.9,21,42,40,108,5.8,0.9,5,8,1.2,37,17,419,0 0,1,1,0,0,1,0,1,?,0,0,1,0,0,1,0,?,?,0,1,1,0,1,88,80,0,2,2,3,1.27,66,10.9,97.3,8.9,270,2.7,2.1,145,84,179,260,5.9,?,5,3,1.3,15,17,639,0 0,1,0,0,0,1,0,1,1,0,0,0,0,0,0,0,0,?,1,1,0,0,1,23,0,0,0,1,1,1.17,358,12.7,74,2.2,51,2.9,2.8,53,41,54,94,4.9,0.2,2,5.4,0.8,50,16,20,1 1,1,1,0,0,0,0,1,0,1,0,0,0,0,0,0,1,0,0,1,1,1,1,59,75,44,3,2,2,1.01,1810346,13,102.1,8300,433000,3.4,1.9,138,86,1575,417,6.5,0.64,5,15,1.1,?,?,?,1 1,1,1,0,0,0,0,1,?,1,0,0,0,1,0,0,0,?,1,1,1,1,0,82,50,48,2,1,2,1.53,33502,14.4,101.1,11.6,109,3.1,2.3,27,80,177,1.28,6.7,1.5,5,4,0.8,26,15,227,1 1,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,?,0,0,1,1,1,67,?,0,0,1,1,0.94,20,13,92,6.9,222000,3.7,0.6,162,354,1390,684,7.1,0.81,5,?,?,?,?,?,0 1,1,1,0,?,0,0,1,0,1,0,0,0,1,0,0,0,1,1,1,0,0,1,61,?,15,0,1,1,1.15,2.5,14.9,92.3,6,159000,3.8,1,28,38,74,101,7.4,1.1,5,7.5,0.3,61,?,255,1 1,1,1,0,?,?,1,1,?,?,0,0,0,0,0,0,0,1,1,1,0,0,1,61,100,?,0,1,1,1.92,2269,12.1,119,5.1,80000,?,9.6,204,357,199,174,?,0.99,1,7.6,4.6,178,90,960,0 1,1,1,0,0,0,0,1,0,?,0,0,0,1,0,0,0,1,0,1,1,0,0,67,?,?,2,1,2,3.16,4181,9.1,103.6,5.1,128000,3,2.2,57,91,115,165,7.7,0.83,1,4.5,1.2,72,29.5,355,0 1,1,1,0,0,0,0,1,?,?,0,0,0,0,0,0,0,?,0,1,0,0,1,78,80,?,0,1,1,1.45,5.1,14.4,100.2,7.1,77000,4.1,0.9,43,63,540,114,7,1.09,5,?,?,?,?,?,1 1,1,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,?,0,1,0,1,1,52,80,?,3,1,1,1.34,345,9.8,81.8,13.6,561,2.6,0.5,43,43,23,88,5.6,?,5,4.7,0.5,19,8,141,1 1,?,1,0,0,0,1,1,?,1,0,0,0,0,0,0,0,1,1,1,0,0,0,51,100,34.5,2,2,2,2.08,2.9,10.4,91.1,5.8,91000,2.4,16,123,145,109,190,5.9,0.9,0,?,9.6,?,?,?,1 1,1,1,?,?,?,?,1,0,?,1,0,0,1,1,0,?,?,1,1,0,1,1,74,?,?,3,2,1,1.32,2.5,12.6,83.7,9.8,102000,3.3,1.2,29,43,196,204,7.3,1.1,5,?,0.5,?,?,?,0 1,0,1,0,?,0,0,1,0,?,1,0,0,0,0,0,0,1,1,1,0,0,1,56,100,?,1,2,1,1.63,5.04,15.8,99,5.8,75000,3.5,4.6,93,85,193,165,6.6,0.7,1,6,1.7,200,87,316,1 1,0,1,0,0,0,0,1,0,0,?,?,?,1,1,0,0,0,?,1,0,0,0,64,100,0,1,1,3,1.71,3.7,14.8,104.3,5.8,56000,2.7,2.6,74,157,311,280,8,0.8,2,3,1.4,?,1.52,859,1 1,1,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,1,1,1,1,0,1,83,100,?,2,1,3,1.48,2.6,12.7,106,3.8,80,2.9,3.4,34,53,156,207,7.2,?,2,4.1,1.4,105,69,221,0 1,?,0,0,0,0,1,1,?,1,1,0,0,1,0,0,0,0,1,0,0,0,1,57,0,?,0,?,?,1.1,2.9,16.4,94.8,4.6,94000,4.1,1.1,104,74,88,85,7.9,1.05,1,5.5,0.3,?,?,?,1 1,1,1,0,0,1,0,1,0,1,0,1,0,0,0,0,0,0,1,1,1,0,1,58,?,10,1,2,1,1.47,20,13.9,100.8,4,112000,3,2.9,50,92,124,244,6.3,0.8,2,6.8,0.7,181,99,108,1 1,1,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,?,0,1,0,1,1,71,?,?,1,1,1,1.08,2.79,12.6,83.9,7100,284000,?,?,28,46,70,213,?,0.48,5,?,?,26,8,?,1 1,0,0,0,0,1,1,1,0,1,0,0,0,0,0,1,0,0,1,1,0,0,1,52,0,33,0,1,2,?,42,15.8,97.9,4.2,142000,4.2,0.5,74,62,38,70,7.5,0.77,3,1.5,?,120,35,30,1 1,1,1,0,0,0,0,1,0,?,1,0,0,0,0,0,0,1,1,1,0,0,1,74,100,?,0,1,2,1.37,457,11.7,70.6,5.7,138000,4.1,2.1,22,33,33,90,9.7,1.6,5,5.6,0.9,13,3,28,0 1,0,1,0,0,1,0,1,0,1,0,0,0,0,0,0,0,1,1,1,0,0,1,61,?,50,1,2,3,1.23,?,9.5,90,7.6,38000,2.2,1.5,59,51,993,474,3.9,2.69,1,2,1,?,?,?,1 1,1,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,1,1,0,1,0,69,100,0,2,1,3,1.41,123,10.1,89.5,2.3,89000,4,4.3,31,60,75,177,6.8,0.7,3,3.5,1,37,11,173,0 1,0,1,0,?,0,0,1,0,?,1,0,0,1,0,0,0,1,1,1,?,?,?,65,?,?,0,1,1,1.22,8.7,14.6,95.1,6.7,142000,4.2,1.3,19,33,346,120,7.8,0.83,?,?,0.3,184,65,423,1 1,1,1,0,0,1,0,1,0,0,1,0,?,1,1,0,0,?,0,1,0,0,1,79,70,0,3,1,1,1.01,226,11.5,95.6,6.3,108,4.2,1,27,31,667,222,6.2,3.13,1,8.8,0.2,?,?,?,0 1,1,1,0,0,0,0,1,0,1,1,1,?,?,0,?,0,?,?,1,1,1,1,69,200,60,1,1,1,1.39,2159,13.1,90.6,10400,261000,3.6,1.9,42,197,552,335,7.1,0.68,5,?,0.6,?,?,?,0 1,?,1,0,0,0,0,1,0,1,1,0,0,1,1,?,0,0,0,0,0,0,1,87,100,50,0,1,1,1.09,48,12.6,97.6,4.9,169000,4.2,0.8,30,31,86,91,6.9,1.9,5,2,?,53,21,278,1 1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,78,0,0,1,1,1,1.6,2.4,9.5,85.8,6900,228000,3.5,0.6,11,17,44,124,6.8,1.6,1,5.5,?,15,7,810,0 1,1,1,0,0,0,1,0,1,0,1,0,0,1,0,0,0,0,0,1,0,0,1,71,?,0,1,1,2,1.11,5,9.1,90.9,6.36,307000,2.47,?,31,29,339,254,5.5,1.18,3,6.3,?,?,?,?,1 1,0,1,0,0,0,0,1,0,?,0,0,?,0,0,0,0,1,1,1,1,0,1,58,?,?,0,1,1,1.64,64,14.1,103.6,4.5,68,2.9,3.3,28,43,51,137,6.8,0.67,4,4.7,1.1,?,?,?,1 1,0,1,0,?,0,0,1,0,?,0,0,0,1,0,0,0,0,0,0,0,0,0,73,?,?,0,1,1,1.23,5.5,13.1,89.6,6.1,160000,3.2,0.8,28,30,90,92,6.3,0.86,5,?,?,93,25,29,1 1,0,1,0,?,0,0,1,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,73,?,0,2,1,2,1.67,8.5,13,102.3,24.8,133000,2.7,9.5,262,335,351,66,6.1,1.2,5,7,5.5,?,?,?,1 1,1,1,?,?,?,0,1,0,0,0,0,0,0,0,?,0,1,1,1,0,1,0,93,?,0,2,1,1,1.16,2785,12,94.4,7.9,78000,2.6,3.5,26,34,339,297,5.7,2.19,5,?,1.5,55,33,256,1 1,1,0,0,0,0,1,1,0,?,0,0,0,1,0,0,0,?,1,1,0,1,1,52,0,?,1,1,3,1.04,6574,13.5,98,4800,77000,3.5,28.9,56,192,464,262,6.9,1.2,5,4,19.5,121,27,749,0 1,1,1,0,0,0,0,1,0,?,0,0,0,1,0,0,?,1,1,1,0,0,1,64,70,?,2,1,2,1.55,5.7,13.9,99.7,5200,124000,2.1,0.8,37,75,203,110,5,0.56,3,2.4,?,92,56,489,1 1,1,0,1,?,?,1,1,?,?,0,0,?,0,0,0,0,?,?,1,0,?,0,63,0,?,4,3,3,1.93,?,13.5,93.3,8190,406000,2.9,40.5,139,266,403,670,6.3,4.82,5,?,29.3,?,?,?,0 1,1,0,0,0,0,0,0,?,1,0,0,0,1,0,0,0,0,0,0,0,0,0,64,0,50,1,1,1,1.17,39,12.6,93.8,4900,144000,3.8,1,42,74,277,312,78,1.01,1,15,?,87,25,81,1 1,1,1,0,0,0,0,1,?,0,0,0,0,1,1,0,0,1,1,1,0,0,1,67,?,0,3,1,2,1.48,2.5,14.3,101.5,5,120,2.2,1.2,34,71,222,97,5.2,2.82,3,2.4,0.3,92,56,48.9,1 1,1,1,0,0,1,1,1,0,1,0,0,0,0,0,0,1,0,1,1,0,0,1,50,80,1,0,1,1,1.18,32,14,90.1,5.2,121000,4.2,0.4,420,226,147,174,8.6,0.9,5,3,?,26.4,54,2230,1 1,1,1,0,0,0,0,1,0,0,1,0,?,0,1,0,0,1,1,1,0,0,1,79,75,0,3,1,2,1.32,7.6,5,69.5,3800,96000,3.7,0.5,17,69,76,86,6.3,2.68,1,10,?,9,3,490,0 1,1,1,0,0,0,0,1,0,0,1,1,0,1,0,0,1,0,0,1,0,1,1,85,100,0,1,1,1,1.25,173,11.3,103.9,6200,176000,2.4,1.7,63,114,80,163,6.1,0.67,5,20,0.5,131,78,1316,0 0,0,1,0,0,0,0,1,?,?,0,0,0,0,0,0,0,1,0,1,0,0,0,62,?,?,0,1,1,1.54,2.3,12.1,89.7,4.5,97000,2.7,1.4,19,27,72,120,4.3,0.61,5,4,0.7,?,?,?,1 1,1,1,1,0,1,0,1,?,1,0,0,0,1,0,0,0,1,1,1,1,1,1,74,200,30,2,2,2,1.26,114,14.9,104.5,4.3,90000,3.2,4.8,106,154,148,166,7.2,0.48,5,12.6,1.8,161,96,297,1 1,1,1,0,0,0,0,1,0,?,0,1,0,0,0,0,0,?,1,1,1,0,1,56,90,?,2,1,2,1.87,173,11.1,105.5,6.1,51000,3.1,32.3,110,206,127,188,5.4,1.29,5,?,22.1,?,?,?,0 1,0,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,1,1,1,0,0,1,74,100,?,0,1,1,1.36,18,15.3,90.9,4.9,81000,4.2,1.7,35,49,97,109,7.3,1.02,1,3.5,0.3,?,?,?,1 1,1,0,1,0,1,0,1,0,1,0,0,0,0,0,0,0,1,1,1,1,1,0,62,0,7.5,1,1,1,1.45,42,16.2,99.1,5.001,77000,4.1,1.3,42,118,279,158,7.7,0.88,2,7.4,0.3,?,?,?,1 1,1,1,0,0,0,0,1,0,?,1,0,?,0,0,0,0,1,1,1,1,0,1,60,100,?,3,3,2,1.87,28274,10.3,94.7,11.1,109000,2.4,5.7,25,111,55,128,7,1.3,1,1.5,1.9,51,18,56,0 1,1,1,0,?,?,0,1,0,1,0,0,0,0,0,0,0,?,?,?,0,0,0,55,100,43,0,1,1,1.23,736,14,88.2,4.68,286000,4.7,0.8,48,113,649,629,8.4,0.71,5,9.1,0.3,?,?,?,1 1,1,1,0,0,0,0,1,0,1,1,0,?,1,0,0,0,1,1,1,0,0,0,57,96,60,0,1,3,1.17,1009,13.8,93.2,3100,137000,3,0.7,25,55,343,235,?,0.79,2,20,?,?,?,?,0 1,1,1,1,1,1,0,1,0,?,0,0,0,0,0,0,0,?,1,1,0,0,0,63,120,?,4,3,2,2.42,22475,12,111.4,9.9,70000,3.28,19,134,178,54,146,8,3.23,1,?,9.7,106,67,2165,0 1,0,1,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,63,?,0,0,1,1,1.28,5.2,14.6,96.1,6.1,194000,4.2,7.9,97,69,816,79,7.7,1.02,1,3,?,?,?,?,1 1,0,1,0,0,0,0,1,0,1,0,0,0,0,0,0,0,1,0,1,0,0,0,79,180,23,0,1,2,1.46,5.2,14.9,103.8,4500,53000,3.2,1.4,62,87,263,239,8.1,0.72,1,1.5,1,?,?,?,1 1,1,0,1,0,?,0,1,1,0,1,0,0,1,0,?,?,?,?,?,0,0,0,63,0,0,1,1,1,1.14,14177,10.2,96.1,6000,109000,2.6,4.9,70,113,833,980,7.5,0.78,5,9,2.8,?,?,?,1 1,0,1,0,0,0,0,1,0,0,1,0,0,0,0,0,0,?,0,0,0,0,1,59,100,0,0,1,1,1.94,3.1,10.8,102.8,5300,97000,3.6,1.1,119,125,663,433,6.5,0.87,2,3.2,0.4,52.5,37,856,0 1,1,1,0,0,1,1,1,0,1,0,0,0,0,0,0,0,1,1,1,1,1,0,51,75,52.5,2,1,1,1.56,50655,9.8,85.6,3900,132000,2.6,2.6,123,219,503,363,7.3,0.55,1,4,1.5,40,12,57,0 1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,?,?,0,0,0,0,1,74,0,0,0,1,1,1.11,1.2,15.1,83.8,5.2,178000,4.7,0.5,35,17,45.3,151,6.4,1.5,1,8.3,?,88,27,90,1 1,1,1,0,0,1,1,1,?,1,0,0,1,0,0,0,?,1,0,1,0,0,0,62,?,?,2,1,2,1.08,657,11.8,89.2,9400,211000,3.2,0.8,43,101,646,466,7.3,0.7,1,8.3,?,?,?,579,0 1,1,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,0,0,1,1,0,1,76,100,?,4,2,2,1.2,421500,14.3,89.5,9.8,309000,3.1,1.5,20,44,291,217,6.3,0.7,1,20,0.5,52,17,832,0 1,0,0,0,0,?,1,1,0,?,1,0,0,0,0,0,0,1,1,1,0,0,1,73,0,?,0,1,1,1.2,472,15.6,88.4,5.5,83000,4,2.4,117,128,249,117,7.2,0.69,1,13,0.7,?,?,?,1 1,0,1,0,0,0,?,1,0,0,1,0,?,1,0,0,0,?,1,1,1,0,1,76,?,0,3,2,1,1.66,77,12.3,104.2,2900,60000,3.2,2.8,54,38,311,182,6.2,0.77,2,4.3,1,93,47,307,1 1,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,?,?,0,0,0,0,72,0,510,2,1,1,1.13,2.1,12.6,95.1,8.7,254000,3.68,0.7,26,38,161,127,6.9,1.11,2,4.3,?,28,10,308,0 0,1,1,?,?,?,?,1,0,0,1,0,0,0,0,?,0,0,0,1,0,0,1,77,75,0,2,2,2,1.07,2,11.6,83.5,9,318000,3.89,0.9,23,48,319,171,7.1,0.66,2,5.8,?,?,?,?,0 0,1,0,?,?,?,0,1,0,0,0,1,0,1,0,?,?,?,0,0,1,1,0,75,0,0,2,1,3,1.22,4.2,14.9,87.4,15.4,179000,3.5,0.6,31,61,196,150,5.4,0.7,5,17.5,0.3,?,?,?,1 0,0,1,?,?,?,0,1,0,?,0,0,0,0,0,0,0,1,0,1,0,0,1,55,100,?,2,2,2,2.5,7.5,11.3,119.6,13.1,135000,3.2,8.6,62,94,82,147,6.5,1,5,2.6,3.8,?,?,?,1 0,0,0,0,0,0,1,1,?,0,1,0,0,0,1,0,0,?,1,0,0,0,0,72,0,0,0,1,1,1.21,152,10.9,99.6,7.3,93000,3.2,1.3,82,80,427,106,7.1,6.1,2,9,0.7,?,?,?,0 0,1,0,?,?,?,?,0,0,0,0,0,?,1,1,0,0,0,0,0,0,1,1,82,0,0,1,1,1,1.09,811,11.4,89.3,9.1,318000,3.4,0.8,77,102,739,587,7.2,2.14,5,16,?,14,5,149,0 0,1,0,?,?,?,?,0,0,0,0,0,0,0,0,?,0,0,0,0,0,0,1,46,0,0,0,1,1,1.42,4.7,14.2,90.3,6690,268000,3.1,0.32,37,44,80,517,5.5,0.7,1,13,0.12,?,?,?,1 0,1,0,0,0,0,0,1,0,0,1,1,0,1,0,0,1,0,0,0,0,1,1,71,0,0,1,1,1,1.24,2.6,13.3,96.4,7.8,280000,4.1,0.6,70,52,141,123,6.8,0.82,5,8.3,?,?,?,?,1 0,1,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,1,1,0,0,1,56,0,40,2,1,1,1.25,2089,15.4,91.6,10.9,175000,4.4,1.3,45,32,717,295,7.4,1.1,5,6,0.6,?,?,?,1 0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,78,0,0,0,2,1,1.03,18,13.2,89.5,2.6,136000,4.3,0.8,18,29,82,141,7.2,0.85,1,9.5,?,91,31,80,1 0,1,0,0,0,1,0,1,?,?,?,?,0,?,?,0,1,0,0,0,0,0,1,55,0,?,0,1,1,1.19,4.9,13.6,97.3,5400,133000,4.5,0.9,54,63,487,89,7.8,0.78,2,3.32,?,78,30,220,1 0,1,1,0,0,1,1,1,0,1,1,1,0,1,0,0,0,0,0,1,0,0,1,76,?,12,2,1,1,0.94,240,14.7,102.3,9.9,267000,3.6,0.5,64,132,356,192,7.4,0.9,3,2,0.4,?,?,?,1 0,1,0,?,?,?,0,1,0,0,0,0,0,0,0,?,0,?,0,0,1,0,0,43,0,0,0,1,1,1.25,180,12.2,87.6,7.2,130,3.5,0.5,79,58,229,302,7,0.6,5,9,?,?,?,206,0 1,1,0,0,0,1,1,1,0,?,0,0,0,0,0,0,0,?,1,1,0,0,0,71,0,?,0,1,1,1.47,15,13.3,89.7,5.7,154000,3.2,1,?,87,120,108,102,0.68,3,2,?,?,?,?,0 1,?,1,0,0,0,1,1,0,0,1,1,1,0,1,0,0,1,0,1,0,0,0,67,70,0,0,1,?,1.02,24,16,98.8,6.6,96000,4.1,1.4,207,158,116,84,7.2,0.9,1,2.2,0.3,?,?,?,1 1,0,1,0,0,0,0,1,0,1,1,1,0,0,0,0,?,1,1,1,0,0,0,67,?,40,0,1,1,1.798,9.4,11.2,102.4,4.1,60000,3.4,3.7,43,63,175,106,7.6,0.52,1,2.1,1.1,94,39,344,1 1,?,1,0,0,1,0,1,0,1,0,0,0,0,0,0,0,?,?,?,0,0,1,51,?,37,0,1,1,1.26,7,14.9,106.3,6.4,122,3,1.5,195,401,272,93,6.4,1,3,2.9,0.4,124,51,642,1 1,1,1,0,0,0,0,1,0,?,?,?,?,?,?,0,?,?,?,?,0,0,0,80,?,?,0,1,1,1,4.8,9.2,94,6.2,157000,3.88,0.76,42,51,983,141,?,1.1,1,15,0.33,?,?,?,1 1,1,1,0,0,0,0,1,?,1,0,1,0,1,1,0,?,1,0,1,1,0,0,79,100,15,2,1,3,1.68,92421,14.3,72.2,13.3,459000,3.2,1.6,24,76,570,472,5.9,2.02,1,?,0.6,29,4,14,0 1,0,1,0,?,0,0,1,?,?,1,1,?,1,0,0,0,1,1,1,0,0,1,75,?,?,0,1,1,1.71,5.2,11.1,106.9,2100,52000,3.3,2.6,15,47,94,117,7.1,0.79,1,3.5,1,?,?,?,1 0,0,0,0,?,0,0,1,?,0,0,0,0,0,0,0,0,1,1,1,0,0,0,81,0,0,0,1,1,1.18,16,13.3,94.3,4800,96000,3.8,1.2,26,35,75,105,7.6,0.53,1,2.4,0.3,?,?,?,1 0,1,0,0,0,0,0,0,?,0,0,0,0,0,0,0,0,1,1,1,1,0,0,25,0,0,2,1,1,?,1.5,?,?,?,?,?,?,?,?,?,?,?,?,1,6.6,?,?,?,?,1 1,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,36,0,0,0,1,1,1.12,3204,16.1,92,10.5,182,4.3,0.7,46,31,92,79,7.3,1,1,?,0.2,?,?,?,1 0,0,1,0,0,0,0,1,0,?,0,0,0,0,0,0,0,1,?,?,0,0,1,69,?,?,0,1,1,1.2,10,13.5,104.9,13.5,194,4,1,31,79,126,85,7.6,0.8,1,7,0.4,?,?,?,1 1,1,1,0,0,0,1,1,0,1,1,0,0,0,1,0,0,1,1,1,0,1,1,47,250,18,1,1,3,1.39,695,11.1,93.9,5.4,88000,2.7,1,31,73,38,44,7,0.96,5,3.5,?,?,?,?,1 1,1,1,?,?,?,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,87,?,0,3,1,1,1.2,33,9.7,91.6,10.1,277,3.8,2.4,60,54,468,338,7,1.13,1,15,1.3,?,?,?,0 0,0,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,1,1,1,0,0,0,36,0,0,0,1,1,1.52,615,11.7,99.7,5.6,70000,2.82,3,66,50,120,318,6.4,0.64,5,1.9,1,?,?,?,1 1,1,1,0,0,0,0,1,?,1,0,0,1,0,0,0,0,?,1,1,1,0,1,64,75,25,3,2,3,1.63,1671,12.8,101.6,4.4,172000,3.44,5.8,38,95,92,139,7.6,0.9,3,9,2.9,111,94,1600,0 1,1,1,0,0,1,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,49,?,0,1,1,1,1.24,975,15.3,103,11.5,124000,3.5,1.2,62,85,561,266,7.5,0.77,1,2.3,0.6,180,70,1176,0 1,?,1,0,0,0,0,1,?,1,0,0,0,1,0,0,0,1,1,1,0,0,1,62,?,20,0,1,2,1.41,1.7,14.7,97.2,6900,72000,3.5,1.3,31,24,67,97,7.3,0.76,1,3.5,0.3,?,?,?,1 1,?,0,0,0,0,0,1,?,?,1,0,0,0,1,0,0,1,1,1,0,0,1,71,0,?,3,1,1,1.16,1713,8.2,94.2,6,209000,3.6,0.3,62,59,450,263,6.8,1.49,1,7.5,?,?,?,?,1 1,1,1,1,0,1,0,1,0,0,0,0,0,0,0,0,0,?,1,1,0,1,1,64,100,0,3,3,3,1.52,4.9,7.9,111.2,4.1,67000,2.43,1.9,40,71,69,73,4.8,0.77,5,3.2,0.7,40,18,283,0 0,0,1,?,?,?,1,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,40,?,?,0,1,1,0.84,?,15.4,109.2,9.3,184000,4.6,0.5,35,40,449,109,7.6,0.7,5,3,?,?,?,?,1 0,1,0,?,?,?,?,1,0,0,0,0,0,1,0,?,0,1,1,1,0,0,1,68,0,0,2,1,1,1.33,4887,12.1,88.9,2.5,141,3,3.6,50,91,147,280,6.7,0.7,1,2.2,2.3,?,?,?,0 1,0,1,0,0,0,0,1,0,1,1,1,0,1,1,0,?,?,?,?,0,0,1,65,?,48,0,1,1,1.13,75,13.3,90,8,385000,4.3,0.6,53,52,164,181,7.5,1.46,5,18.6,?,?,?,?,1 1,0,1,1,0,1,1,1,1,1,0,0,0,0,0,1,0,?,?,?,1,1,1,44,?,?,2,1,1,2.14,94964,15.6,117.3,5200,118000,4.8,1.1,50,60,320,170,8.4,0.74,5,18,?,?,?,?,0 1,1,1,0,0,0,1,1,0,1,0,0,0,0,0,0,0,?,1,1,0,1,1,52,50,?,0,1,1,1.79,44340,12.7,95.8,14.4,412000,2.2,28.5,78,127,444,462,6.6,3.95,5,8.5,19.8,?,?,?,0