% % !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! % % Case number deleted. X treated as the class attribute. % % As used by Kilpatrick, D. & Cameron-Jones, M. (1998). Numeric prediction % using instance-based learning with encoding length selection. In Progress % in Connectionist-Based Information Systems. Singapore: Springer-Verlag. % % !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! % % NAME: PBC Data % SIZE: 418 observations, 20 variables % % % % DESCRIPTIVE ABSTRACT: % % Below is a description of the variables recorded from the Mayo Clinic trial % in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and % 1984. A total of 424 PBC patients, referred to Mayo Clinic during % that ten-year interval, met eligibility criteria for the randomized placebo % controlled trial of the drug D-penicillamine. The first 312 cases in the data % set participated in the randomized trial, and contain largely complete data. % The additional 112 cases did not participate in the clinical trial, but % consented to have basic measurements recorded and to be followed for survival. % Six of those cases were lost to follow-up shortly after diagnosis, so there % are data here on an additional 106 cases as well as the 312 randomized % participants. Missing data items are denoted by ".". At least one space % separates each variable in the .DAT file. Censoring was due to liver % transplantation for twenty-five subjects with the following case numbers: % 5, 105, 111, 120, 125, 158, 183, 241, 246, 247, 254, 263, 264, 265, 274, % 288, 291, 295, 297, 345, 361, 362, 375, 380, 383. % % % % SOURCE: Counting Processes and Survival Analysis by T. Fleming & % D. Harrington, (1991), published by John Wiley & Sons. % % % % VARIABLE DESCRIPTIONS: % % The data are in free format. That is, at least one blank space separates % each variable. The variables contained in the .DAT are: % % % N: Case number. % X: The number of days between registration and the earlier of % death, liver transplantation, or study analysis time in July, 1986. % D: 1 if X is time to death, 0 if time to censoring % Z1: Treatment Code, 1 = D-penicillamine, 2 = placebo. % Z2: Age in years. For the first 312 cases, age was calculated by % dividing the number of days between birth and study registration by 365. % Z3: Sex, 0 = male, 1 = female. % Z4: Presence of ascites, 0 = no, 1 = yes. % Z5: Presence of hepatomegaly, 0 = no, 1 = yes. % Z6: Presence of spiders 0 = no, 1 = Yes. % Z7: Presence of edema, 0 = no edema and no diuretic therapy for % edema; 0.5 = edema present for which no diuretic therapy was given, or % edema resolved with diuretic therapy; 1 = edema despite diuretic therapy % Z8: Serum bilirubin, in mg/dl. % Z9: Serum cholesterol, in mg/dl. % Z10: Albumin, in gm/dl. % Z11: Urine copper, in mg/day. % Z12: Alkaline phosphatase, in U/liter. % Z13: SGOT, in U/ml. % Z14: Triglycerides, in mg/dl. % Z15: Platelet count; coded value is number of platelets % per-cubic-milliliter of blood divided by 1000. % Z16: Prothrombin time, in seconds. % Z17: Histologic stage of disease, graded 1, 2, 3, or 4. % % % % % STORY BEHIND THE DATA: % % Between January, 1974 and May, 1984, the Mayo Clinic conducted a % double-blinded randomized trial in primary biliary cirrhosis of the liver % (PBC), comparing the drug D-penicillamine (DPCA) with a placebo. There % were 424 patients who met the eligibility criteria seen at the Clinic while % the trial was open for patient registration. Both the treating physician and % the patient agreed to participate in the randomized trial in 312 of the 424 % cases. The date of randomization and a large number of clinical, biochemical, % serologic, and histologic parameters were recorded for each of the 312 % clinical trial patients. The data from the trial were analyzed in 1986 for % presentation in the clinical literature. For that analysis, disease and % survival status as of July, 1986, were recorded for as many patients as % possible. By that date, 125 of the 312 patients had died, with only 11 % not attributable to PBC. Eight patients had been lost to follow up, and 19 % had undergone liver transplantation. % % PBC is a rare but fatal chronic liver disease of unknown cause, % with a prevalence of about 50-cases-per-million population. The primary % pathologic event appears to be the destruction of interlobular bile ducts, % which may be mediated by immunologic mechanisms. The data discussed here are % important in two respects. First, controlled clinical trials are difficult to % complete in rare diseases, and this case series of patients uniformly % diagnosed, treated, and followed is the largest existing for PBC. The % treatment comparison in this trial is more precise than in similar trials % having fewer participants and avoids the bias that may arise in comparing % a case series to historical controls. Second, the data present an % opportunity to study the natural history of the disease. We will see that, % despite the immunosuppressive properties of DPCA, there are no detectable % differences between the distributions of survival times for the DPCA and % placebo treatment groups. This suggests that these groups can be combined % in studying the association between survival time from randomization and % clinical and other measurements. In the early to mid 1980s, the rate of % successful liver transplant increased substantially, and transplant has % become an effective therapy for PBC. The Mayo Clinic data set is therefore % one of the last allowing a study of the natural history of PBC in patients % who were treated with only supportive care or its equivalent. The PBC data % can be used to: estimate a survival distribution; test for differences % between two groups; and estimate covariate effects via a regression % model. % @relation 'pbc' @attribute 'D' { 1, 0} @attribute 'Z1' { 1, 2} @attribute 'Z2' real @attribute 'Z3' { 1, 0} @attribute 'Z4' { 1, 0} @attribute 'Z5' { 1, 0} @attribute 'Z6' { 1, 0} @attribute 'Z7' { 1, 0, 0.500000} @attribute 'Z8' real @attribute 'Z9' real @attribute 'Z10' real @attribute 'Z11' real @attribute 'Z12' real @attribute 'Z13' real @attribute 'Z14' real @attribute 'Z15' real @attribute 'Z16' real @attribute 'Z17' { 4, 3, 2, 1} @attribute 'class' real @data 1,1,58.7652,1,1,1,1,1,14.5,261,2.6,156,1718,137.95,172,190,12.2,4,400 0,1,56.4463,1,0,1,1,0,1.1,302,4.14,54,7394.8,113.52,88,221,10.6,3,4500 1,1,70.0726,0,0,0,0,0.500000,1.4,176,3.48,210,516,96.1,55,151,12,4,1012 1,1,54.7406,1,0,1,1,0.500000,1.8,244,2.54,64,6121.8,60.63,92,183,10.3,4,1925 0,2,38.1054,1,0,1,1,0,3.4,279,3.53,143,671,113.15,72,136,10.9,3,1504 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0,?,49,?,?,?,?,0,18,?,3.04,?,?,?,?,432,9.7,?,2267 0,?,44,?,?,?,?,0,0.6,?,3.5,?,?,?,?,150,9.9,?,2249 1,?,59,?,?,?,?,0,2.7,?,3.35,?,?,?,?,142,11.5,?,359 0,?,63,?,?,?,?,0,0.9,?,3.58,?,?,?,?,224,10,?,1925 1,?,61,?,?,?,?,0,1.3,?,3.01,?,?,?,?,223,10.7,?,249 0,?,64,?,?,?,?,0,1.1,?,3.49,?,?,?,?,166,9.8,?,2202 1,?,49,?,?,?,?,0,13.8,?,2.77,?,?,?,?,388,?,?,43 1,?,42,?,?,?,?,0,4.4,?,4.52,?,?,?,?,102,10.8,?,1197 1,?,50,?,?,?,?,0,16,?,3.36,?,?,?,?,384,10,?,1095 1,?,51,?,?,?,?,0.500000,7.3,?,3.52,?,?,?,?,265,11.1,?,489 0,?,37,?,?,?,?,0,0.6,?,3.55,?,?,?,?,248,10.3,?,2149 0,?,62,?,?,?,?,0,0.7,?,3.29,?,?,?,?,190,9.8,?,2103 0,?,51,?,?,?,?,0,0.7,?,3.1,?,?,?,?,274,10.6,?,1980 0,?,52,?,?,?,?,0,1.7,?,3.24,?,?,?,?,231,10.5,?,1347 1,?,44,?,?,?,?,0,9.5,?,3.63,?,?,?,?,292,10.2,?,1478 0,?,33,?,?,?,?,0,2.2,?,3.76,?,?,?,?,253,9.9,?,1987 1,?,60,?,?,?,?,0.500000,1.8,?,3.62,?,?,?,?,225,9.9,?,1168 1,?,63,?,?,?,?,0.500000,3.3,?,2.73,?,?,?,?,224,11.1,?,597 0,?,33,?,?,?,?,0,2.9,?,4.08,?,?,?,?,418,10.5,?,1725 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0,?,44,?,?,?,?,0,0.5,?,3.34,?,?,?,?,258,10.6,?,1223 1,?,69,?,?,?,?,0,4.2,?,3.19,?,?,?,?,120,11.1,?,935 0,?,52,?,?,?,?,0,0.8,?,3.01,?,?,?,?,256,10.6,?,943 0,?,66,?,?,?,?,0,2.5,?,3.33,?,?,?,?,256,10.8,?,1141 0,?,40,?,?,?,?,0,4.6,?,3.6,?,?,?,?,337,10.4,?,1092 0,?,52,?,?,?,?,0,1,?,3.64,?,?,?,?,340,10.6,?,1150 1,?,46,?,?,?,?,0,4.5,?,2.68,?,?,?,?,219,11.5,?,703 0,?,54,?,?,?,?,0,1.1,?,3.69,?,?,?,?,220,10.8,?,1129 0,?,51,?,?,?,?,0.500000,1.9,?,3.17,?,?,?,?,162,10.7,?,1086 0,?,43,?,?,?,?,0,0.7,?,3.73,?,?,?,?,214,10.8,?,1067 0,?,39,?,?,?,?,0,1.5,?,3.81,?,?,?,?,255,10.8,?,1072 0,?,51,?,?,?,?,0,0.6,?,3.57,?,?,?,?,286,10.6,?,1119 0,?,67,?,?,?,?,0,1,?,3.58,?,?,?,?,244,10.8,?,1097 0,?,35,?,?,?,?,0,0.7,?,3.23,?,?,?,?,312,10.8,?,989 1,?,67,?,?,?,?,0,1.2,?,2.96,?,?,?,?,174,10.9,?,681 0,?,39,?,?,?,?,0,0.9,?,3.83,?,?,?,?,180,11.2,?,1103 0,?,57,?,?,?,?,0,1.6,?,3.42,?,?,?,?,143,9.9,?,1055 0,?,58,?,?,?,?,0,0.8,?,3.75,?,?,?,?,269,10.4,?,691 0,?,53,?,?,?,?,0,0.7,?,3.29,?,?,?,?,350,10.6,?,976